51 REGULATION OF SOMATOMEDIN-BINDNING PROTEIN
نویسندگان
چکیده
منابع مشابه
Somatomedin and the regulation of skeletal growth.
Somatomedin is a polypeptide(s) which "mediates" the actions of growth hormone. This pituitary dependent hormone was previously called "sulfation factor," a term derived from the bioassay technique which measures the incorporation of radioactive sulfate into cartilage glycosaminoglycans. Somatomedin has a more general effect upon cartilage; it is necessary for the cell multiplication and cartil...
متن کاملPlasma somatomedin activity in protein calorie malnutrition.
Somatomedin activity was assayed in the plasma of children suffering from protein calorie malnutrition by a bioassay using rat cartilage and expressed as sulphate uptake ratio. The sulphate uptake ratio was particularly reduced in kwashiorkor. In marasmus there was a slight reduction and the levels were still in the normal range. Plasma growth hormone (GH) levels were raised in kwashiorkor but ...
متن کاملCloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.
By N-terminal sequence comparison it was shown that the placental protein 12 (PP12)(1) is homologous to the IGF I (insulin-like growth factor) and somatomedin binding protein (2-4). Starting with an antibody raised against PP12 we have screened cDNA libraries from human placenta. Two cDNA clones were identified with an open reading frame encoding a hydrophobic leader peptide consisting of 25 aa...
متن کاملThe somatomedin hypothesis: 2001.
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissue...
متن کاملDietary constituents and somatomedin activity.
Serum somatomedin activity of rats was measured under several dietary conditions by 35S incorporation into chick embryo pelvic rudiment. The mean (+/- SD) serum somatomedin activity (U/ml) was reduced following 3 days of fasting (0.41 +/- 0.12) and increased to prefasting levels in animals fed a balanced diet (0.95 +/- 0.11) for 2 days. The increase in mean somatomedin activity following 2 day...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198506000-00071